Allergic and toxic reactions to seafood
Seafood allergy occurs most commonly where seafood is an important part of the diet, such as in Asia and Scandinavia. Some conditions caused by toxins or parasites in seafood can resemble allergic reactions to seafood.
Seafood allergy is not rare
Whilst figures vary from country to country, approximately 1% of the population is estimated to suffer from seafood allergy. It is more common in teenage and adult life than very early childhood. About 20% will grow out of their allergy with time.
Symptoms of seafood allergy
Many allergic reactions to seafood are mild and cause hives (urticaria), swelling (angioedema) and/or gut reactions (vomiting, diarrhoea).
The most dangerous symptoms are breathing difficulties or collapse, caused by a drop in blood pressure (shock), either of which can be life threatening. This is known as anaphylaxis, a severe allergic reaction.
Occasionally, breathing difficulties may occur from inhaling fumes when seafood is being cooked, and in seafood processing factories. Children with a history of asthma may be more likely to have severe allergic reactions to seafood.
Varieties of seafood
The major groups of seafood that can trigger allergic reactions are:
- Vertebrates (fish with a backbone)
including salmon, cod, mackerel, sardines, herring, anchovies, tuna, trout, haddock, John Dory, eels, rays.
- Invertebrates (no backbone) crustaceans including prawns/shrimps, lobster, crab, crayfish, yabbies; and molluscs including oysters, mussels, clams, octopus, squid, calamari, abalone, sea slugs.
Allergies may occur to one or many foods
Even though fish and shellfish live in the same place, the protein allergens present in one seafood group are generally considered to be very different to those in others. That means that one can be allergic to fish only, shellfish only or members of both groups. People who are allergic to one fish are usually (but not always) allergic to most other fish. Similarly, allergy to one crustacean usually means that all must be avoided. While those allergic to seafood from one group (e.g. crustaceans) can usually tolerate those from another (e.g. molluscs), this cannot be guaranteed without specific allergy testing.
Cross reactivity can be difficult to predict without testing
Cross reactivity means that a similar protein is present in a range of different foods. If the same protein is present in several foods, then that person may have allergic reactions to any food containing that protein. Examples of cross reactivity include people allergic to similar proteins present in one fish that are also present in other fish, or those allergic to proteins present in prawn, crab and lobster. Unfortunately, it is sometimes difficult to predict whether a person will be allergic to one unique protein allergen present in one food only, or several similar cross reactive proteins present in multiple foods, simply based on whether foods have a similar appearance. Therefore it is not possible to reliably predict the likelihood of allergy to one or more seafood group or individual seafood species without specific testing.
Cooking can sometimes affect tolerance
Seafood allergens are usually very heat stable and cannot easily be destroyed through cooking, although occasional individuals seem to tolerate tinned fish (intensely heat treated) yet are unable to tolerate the same fish freshly cooked. Do not try tinned fish unless advised by your allergy specialist.
Exposure may occur via multiple routes
While eating the food is the major trigger for allergic reactions, some sensitive individuals may react to the fumes when seafood is being cooked, and occasionally from touch, such as when cleaning and handling fish or even “injected”, such as penetration of the skin from fish hooks. Occupational asthma and contact rashes can also be a problem where exposure is frequent, such as in seafood processing factories, or in some food handlers such as chefs.
Delayed reactions to seafood
Allergic symptoms after contact with seafood are usually within minutes, however, delayed type reactions and particularly exercise-induced anaphylaxis is occasionally observed, particularly after ingestion of shellfish (such as oyster, abalone, squid and shrimp).
Avoiding seafood groups is an important part of management
Complete avoidance of one or more groups of seafood is often advised, yet this can be difficult. Accidental exposure is more likely to occur when eating away from home, particularly when eating at seafood restaurants.
Other potential sources of accidental exposure and cross-contamination include:
- Seafood platters and smorgasbords (best avoided).
- Asian foods, in which shellfish can be a common ingredient or contaminant (such as prawns in fried rice or soups, seafood extender).
- Food may be rolled in the same batter or cooked in the same oil as seafood (such as takeaway fish and chips).
- Commercial pizzas, where contamination may occur by virtue of the method of preparation.
- Seafood purchased from an outlet where both fish and shellfish are sold. Fish could be contaminated with shellfish and vice versa.
- Anchovies in Caesar salads and as an ingredient of Worcestershire sauce.
- Contaminated barbeques.
- Isinglass is sometimes used as a “fining” agent to remove cloudiness from beer and wine. Made from the swim bladder of certain types of fish, it consists almost entirely of collagen, and is considered very unlikely to cause allergic reactions. Use of isinglass in beer and wine has been exempted from mandatory labelling regulations in Australia.
- While the risk of allergic reactions to fish oils is considered to be very low in those allergic to fish due to the method of purification, those with fish allergy are advised to seek medical advice before consuming. Other sources of omega-3 fatty acids include evening primrose oil and flaxseed oil.
Immunotherapy to “switch off” food allergy is not currently available, although this is an active area of research.
Seafood allergy and iodine allergy are unrelated
People allergic to seafood have allergic reactions to proteins present in the animal, not to iodine, which may be present as well. People who are allergic to seafood are not at an increased risk of allergic reactions to iodine (e.g. topical antiseptics such as Betadine or Povidine or intravenous x-ray radio-contrast agents). Conversely, people with iodine allergy are not at increased risk of seafood allergy.
Glucosamine is derived from shellfish
Glucosamine is a popular complementary medicine, used to treat osteoarthritis, which is derived from the outer coatings of shellfish such as crustaceans. Sometimes chondroitin sulphate is added, usually derived from shark cartilage. While people allergic to shellfish are sensitive to protein and not shell constituents, tests to exclude protein contamination are not routinely performed and there is little proof of safety in people with shellfish allergy, although challenge studies of small numbers of patients have demonstrated tolerance. Products registered in Australia and New Zealand carry labels warning against their use in people allergic to shellfish/crustaceans. This risk is considered to be very low. Nonetheless, “vegetarian” glucosamine is available which does not contain seafood allergen as it is produced in bacteria cultures.
Reliable diagnosis of food allergy is important
Your doctor will normally ask a series of questions that may help to narrow down the list of likely causes of allergy such as foods or medicines consumed that day, or exposure to stinging insects. This approach will also help to exclude conditions that can sometimes be confused with food allergy. Skin or blood allergen specific IgE allergy tests help confirm or exclude potential triggers. While the results of allergy testing are a guide to whether the person is allergic, results are not a reliable guide to whether the reaction will be mild or severe. It is also important to be aware that it may not be possible to test for all seafood species using commercial skin prick or blood allergy testing, since these are not available for all seafood species. For this reason, some allergy clinics will recommend that you bring samples of fresh food for testing.
Food allergy does not usually run in families
Most of the time, children with food allergy do not have parents with food allergy. However, if a family has one child with food allergy, their brothers and sisters are at a slightly higher risk of having food allergy themselves, although that risk is still relatively low. Some parents want to have their other children screened for food allergy. If the test is negative, that may be reassuring, but does not mean that the other child will never develop an allergy later. If their screening test is positive, it is not always clear whether it definitely represents allergy, or whether the sensitisation detected by the test is clinically irrelevant. The term "false positive" is sometimes used to describe this.
A positive allergy test is not the same as being food allergic
It is important to know that a positive skin or blood allergy test means that the body's immune system has produced a response to a food, but sometimes these are false positives. In other words, the test may be positive yet the person can actually eat the food without a problem. For that reason, it is important to eventually confirm the significance of a positive allergy test (in some circumstances) with a deliberate supervised food challenge. In a child with a positive test of uncertain meaning, this is often done around school age under medical supervision. Interpretation of test results and a decision whether or not a food challenge should be undertaken will usually be made after discussion with a medical specialist (Allergist / Clinical Immunologist).
Unorthodox so-called allergy tests are unproven
There are several methods of unorthodox so-called ‘tests for food allergy’. Examples include cytotoxic food testing, Vega testing, kinesiology, iridology, pulse testing, Alcat testing, allergy elimination and Rinkel's intradermal skin testing. These are unreliable, have no scientific basis and have no useful role in the assessment of allergy. So if you suspect a possible food allergy, have the suspicion confirmed with a reliable test
Some adverse reactions can resemble seafood allergic reactions
Some conditions caused by adverse reactions to seafood can resemble allergic reactions. These include:
Scombroid Fish Poisoning
This is an allergy like reaction that occurs after eating fish that have been improperly refrigerated after capture. Bacteria in and on the fish break down proteins into histamine, one of the major mediators of allergic reactions. Fish with a high content of red meat, which turns brown upon cooking are commonly involved such as mackerel, tuna, king fish, herring, sardines, marlin, anchovies and bluefish. Affected fish often have a metallic or peppery taste. Symptoms usually commence within 30 minutes of eating, and include flushing, itch, hives (urticaria), nausea, vomiting, stomach cramps, dizziness, palpitations and headache. Severe episodes may result in wheezing and dizziness or a drop in blood pressure. Mild symptoms may be treated with antihistamines. If severe symptoms are experience, then urgent medical assistance should be sought. Treatment usually involves taking antihistamines although in a hospital setting, adrenaline may also be given. Scombroid poisoning can be different by the pattern of symptoms and the absence of reactions with skin or blood allergy testing.
This is a nematode (worm) that is a fish parasite. It is found in most parts of the world and also in Australia [see reference below]. Cooking at temperatures above 60oC or storage in industrial freezers for 2 days is required to kill the parasite. Fish that has been left for 48 hours or longer since being frozen should be discarded. Anasakis can cause two major problems in humans:
- Anisakis infection (anisakiasis) can result from eating raw, pickled or undercooked seafood such as sushi. Infection may cause nausea, vomiting, stomach pain, and sometimes appendicitis, bowel blockage or bleeding. Symptoms can occur due to inflammation in the gut at the site of entry of the parasite. Diagnosis requires an endoscopy where a specialist doctor uses a tube to observe the inside of the stomach and bowel without the need for major surgery and from which the parasite can be seen.The parasite usually gets destroyed by our immune system after 3 weeks.
- Anisakis allergy resembles other allergic reactions to food. In this case, the allergy is to the fish parasite, not to the fish itself. Reactions thus occur sometimes after eating seafood, rather than on every occasion. The allergens of Anisakis simplex appear to be not destroyed by heat or cooking and so allergic reactions may be triggered by dead parasites in fish that have been well cooked. Blood allergy testing is available to confirm suspected sensitivity to this parasite.
Ciguatera Poisoning, Paralytic Shellfish Poisoning and Diarrhoetic Shellfish Poisoning
Ciguatera poisoning is caused by eating seafood that has been contaminated by algae-derived toxins. Ciguatera toxins are only present in fish, particularly large reef fish in the tropics. By contrast, paralytic shellfish poisoning and diarrhoetic shellfish poisoning is caused by shellfish contaminated with microorganisms (i.e. algae producing toxins), in particular mussels and oysters. These toxins or poisons interfere with the function of nerve endings. Symptoms occur within 2 to 3 hours of eating contaminated food, and consist of tingling of the lips, tongue and throat, often followed by stomach upset, headache, fever, muscle aches and pains and in the case of ciguatera poisoning, sometimes changes in blood pressure and heart rhythm. Numbness, collapse, coma and confusion have also been described. Most people recover within a few days or weeks with supportive treatment.
Metabisulfite preservative can sometimes be used to stop crustaceans (such as prawns) from discolouring. Reactions to this preservative (also used in wine, beer and some dried fruit as a preservative) include wheezing/tight chest (more common in those with asthma), stomach irritation (e.g. nausea, pain) and very uncommonly, itch/rashes.
Table: Adverse reactions to seafood produced by various substances.
Time of onset
Hepatitis A, Rota-, Astrovirus,
Small round Viruses etc.
All fish and some
2) Ciguatera toxin
3) Algae toxins
1) Fish, particularly with dark meat
2) Reef Fish
3) All Mollusc species
1. Sicherer SH. Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 2001: 108: 881-90.
2. Tanaka, R., K. Ichikawa, et al. Clinical characteristics of seafood allergy and classification of 10 seafood allergens by cluster analysis Arerugi 2000; 49(6): 479-86.
3. Gracia-Bara, M. T., V. Matheu, et al. Anisakis simplex-sensitized patients: should fish be excluded from their diet? Ann Allergy Asthma Immunol 2001; 86(6): 679-85.
4. Trujillo Mf, M. J., A. Rodriguez, et al. Dietary recommendations for patients allergic to Anisakis simplex. Allergol Immunopathol 2002; (Madr) 30(6): 311-4.
5. Coakley, F. V. and D. M. Panicek. Iodine allergy: an oyster without a pearl? AJR Am J Roentgenol 1997; 169(4): 951-2.
6. Leder, R. How well does a history of seafood allergy predict the likelihood of an adverse reaction to i.v. contrast material? AJR Am J Roentgenol 1997; 169(3): 906-7.
7. Lehane, L. Update on histamine fish poisoning. Med J Aust 2000; 173(3): 149-52.
8. Fenner, P. J., R. J. Lewis, et al A Queensland family with ciguatera after eating coral trout. Med J Aust 1997; 166(9): 473-5.
9. Mines, D., S. Stahmer, et al. Poisonings: food, fish, shellfish. Emerg Med Clin North Am 1997; 15(1): 157-77.
10. Ting, J. Y., A. F. Brown, et al. Ciguatera poisoning: an example of a public health challenge. Aust N Z J Public Health 1998; 22(1): 140-2.
11. Lehane L Paralytic shellfish poisoning: a potential public health problem. Med J Aust. 2001; 175: 29-31.
12. Gray HC, Hutcheson PS, Slavin RG. Is glucosamine safe in patients with seafood allergy? J Allergy Clin Immunol. 2004; 114(2):459-60.
13. Rolland JM, Apostolou E, et al. Potential food allergens in wine: Double-blind, placebo-controlled trial and basophil activation analysis. Nutrition 2006;22(9):882-888.
14. Pascual CY, Reche M, et al. Fish allergy in childhood. Pediatr Allergy Immunol 2008: 19; 573-9.
15. Lopata AL, O’Hehir RE, Lehrer SB. Shellfish allergy. Clin Exp Allergy. 2010;40:850-858.
16. Kamath SD, Abdel Rahman AM, Komoda T, Lopata AL. Impact of heat processing on the detection of the major shellfish allergen tropomyosin in crustaceans and molluscs using specific monoclonal antibodies. Food Chem. 2013 Dec 15;141(4):4031-9.
17. Sharp MF, Lopata AL. Fish Allergy: In Review. Clin Rev Allergy Immunol. 2013 Feb 27.
18. Turner P, Ng I, Kemp A, Campbell D. Seafood allergy in children: a descriptive study. Annals of Allergy, Asthma & Immunology. 2011;106(6):494-501.
19. Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of seafood allergy in the United States determined by a random telephone survey. J Allergy Clin Immunol. 2004;114: 159-165.
20. Kandyil RM, Davis CM. Shellfish allergy in children. Pediatr Allergy Immunol. 2009;20: 408-414.
21. Helbling A, Haydel R, McCants ML, Musmand JJ, El-Dahr J, Lehrer SB. Fish allergy: is cross-reactivity among fish species relevant? Double-blind placebo-controlled food challenge studies of fish allergic adults. Annals Allergy Asthma Immunol. 1999;83: 517-523
22. Lopata AL, Lehrer SB. New insights into seafood allergy. Curr Opin Allergy Clin Immunol. 2009;9: 270-277.
23. Van Do T, Elsayed S, Florvaag E, Hordvik I, Endresen C. Allergy to fish parvalbumins: Studies on the cross-reactivity of allergens from 9 commonly consumed fish. J Allergy Clin Immunol. 2005; 116: 1314-1320.
24. Villacis J, Rice TR, Bucci LR, El-Dahr JM, Wild L, Demerell D, Soteres D, Lehrer SB. Do shrimp-allergic individuals tolerate shrimp-derived glucosamine? Clin Exp Allergy 2006; 36:1457–1461
25. Audicana MT, Kennedy MW. Anisakis simplex: from obscure infectious worm to inducer of immune hypersensitivity. ClinMicrobiol Rev 2008; 21:360–379.
26. Priftis KN, Mermiri D, Papadopoulou A, Papadopoulos M, Fretzayas A, Lagona E. Asthma symptoms and bronchial reactivity in school children sensitized to food allergens in infancy. J Asthma 2008; 45:590–595.
( Replace 24. With: Lopata AL, Jeebhay MF. Airborne seafood allergens as a cause of occupational allergy and asthma. Curr Allergy Asthma Rep. 2013 Jun;13(3):288-97.
28. Lopata AL, Zinn C, Potter PC. Characteristics of hypersensitivity reactions and identification of a unique 49 kD IgE-binding protein (Hal-m-1) in abalone (Haliotis midae). J Allergy Clin Immunol 1997; 100:642–8.
Sh amsi S, Eisenbarth A, Saptarshi S, Beveridge I, Gasser RB, Lopata AL. Occurrence and abundance of anisakid nematode larvae in five species of fish from southern Australian waters. Parasitology Research, 2010 E-pub Nov 6.
29. Nieuwenhuizen NE, Lopata AL. Anisakis - A food-borne parasite that triggers allergic host defences. Int J Parasitol. 2013 Nov;43(12-13):1047-57.
30. Rolland JM, Apostolou E, Deckert K, de Leon MP, Douglass JA, Glaspole IN,, Bailey M, Stockley CS, O'Hehir RE. Potential food allergens in wine: double-blind, placebo-controlled trial and basophil activation analysis. Nutrition. 2006 Sep;22(9):882-8.
31. Kirschner S, Belloni B, Kugler C, Ring J, Brockow K. Allergenicity of wine containing processing aids: adouble-blind, placebo-controlled food challenge. J Investig Allergol Clin Immunol. 2009;19(3):210-7.
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This document has been developed and peer reviewed by ASCIA members and is based on expert opinion and the available published literature at the time of review. Information contained in this document is not intended to replace medical advice and any questions regarding a medical diagnosis or treatment should be directed to a medical practitioner. Development of this document is not funded by any commercial sources and is not influenced by commercial organisations.
Content last updated 2014