©2022 Australasian Society of Clinical Immunology and Allergy (ASCIA)
ABN 45 615 521 452


Guide – Setting up a Subcutaneous Immunoglobulin (SCIg) program in a hospital

pdfASCIA HP Guide setting up SCIg Program 2019236.51 KB

Immunoglobulin replacement therapy (IRT) is the standard treatment for most children and adults with primary immune deficiencies and some other medical conditions.  The aim is to replace immunoglobulin to maintain normal IgG levels. The dose used is individualised for each patient. IRT may be given as intravenous immunoglobulin (IVIg) or subcutaneous immunoglobulin (SCIg) and pharmacokinetics differ according to administration route.

When prescribing SCIg or IVIg, you must ensure that doses are rounded to the full vial size. Immunoglobulin is a plasma derived product and is a limited resource. Prescribing a dose that uses a partial vial results in unnecessary wastage.  Vial sizes vary between different products.  This must be taken into account before prescribing.

Whilst there are multiple brands that may change over time and rates of administration vary for different products, both IVIg and SCIg:

Issues to consider when setting up a SCIg service

Table 1: Comparison of Pros and Cons of IVIg and SCIg therapy      





  • Less frequent infusion (monthly)
  • Rapid increase in serum IgG
  • Does not require patient training
  • Usually hospital based
  • IV access required
  • Risk of immediate and systemic adverse effects
  • Adverse effects from high IgG levels in 12-48 hours post infusion
  • Symptoms related to wear off effects of IgG trough levels


  • Home based therapy
  • IV access not needed
  • Few systemic side effects
  • Can be used for patients with previous systemic reactions to IVIg or IV access difficulties - SCIg therapy may be the preferred treatment in these patients
  • Faster infusion duration
  • More consistent IgG levels with no wearing off effects related to IgG trough levels 
  • Improved QOL of patient and family with flexibility, independence and empowerment
  • Reduced hospital costs
  • Reduced patient travel time and associated costs and inconveniences (e.g. time off school/ work, parking costs).
  • Patient can take treatment with them when travelling (e.g. on holiday)
  • Frequent administration (1-3 times per week)
  • Local side effects (swelling, induration, local inflammation, itch), which are usually mild and transient
  • Some patients may require battery or spring driven pumps, although some patients may use the rapid push method which does not require a pump.
  • Requires treatment plan compliance

Source:  Adapted from APIIEG

Table 2: Comparison of Pros and Cons of SCIg infusion methods





Rapid Push

  • Inexpensive (no pump required)
  • Self-empowerment
  • Rapid infusion rate (short duration)
  • Portable and flexible
  • Can be used when pump fails  
  • Requires manual strength and dexterity
  • Manual operation required for the duration of the infusion
  • Larger bore/gauge needle required for infusing

Mechanical infusion pumps:

Spring loaded

(e.g. Springfusor, SCIG 60, Freedom 60)

  • Relatively inexpensive device
  • Robust (no electronics) and doesn’t require servicing
  • Doesn’t require programming
  • Lightweight, portable and flexible
  • Automated
  • Relatively expensive consumable costs
  • Limited control of infusion rate and duration in some devices

Mechanical infusion pumps:

Battery powered

(e.g. Nikki T 34, T34L)

  • Relatively inexpensive consumable costs
  • Automated
  • Infusion rate and duration can be controlled
  • Portable and flexible
  • Usage and compliance can be monitored
  • Relatively expensive device cost
  • Requires service and careful handling
  • Requires programming and set up
  • Batteries require recharging or replacing
  • Repairs may be challenging for rural or remote patients 

Table 3: Suppliers of SCIg equipment - pumps and consumables 

  Supplier Website

Niki T34 syringe driver 

Caesarea Medical Electronics

IDFNZ will fund members in NZ

SCIg 60 infusion system 

EMED Technologies

Go Medical Springfusor® 

LTR Medical   

Freedom 60 infusion system 

Medical Devices

Freedom Edge infusion system 

Medical Devices

Winged infusion sets (25 or 24 gauge) 


Soft-Glide single lumen or double lumen sets (various gauge sizes)

EMED Technologies

Neria® single lumen or multi-lumen sets 


HIgH Flo single lumen or multi-lumen sets 

Medical Devices

Go Medical FCT (flow control tubing) for Springfusor® (various flow rates) 

LTR Medical

© ASCIA 2019

ASCIA is the peak professional body of clinical immunology/allergy specialists in Australia and New Zealand. 

ASCIA resources are based on published literature and expert review, however they are not intended to replace medical advice.  

This resource has been developed independently by ASCIA as part of the ASCIA SCIg project.  Whilst CSL Behring provided an educational grant to assist this project, the content is not influenced by any commercial organisations. 

Content updated December 2019