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Anaphylaxis now more prevalent in older children and adolescents

July 15, 2015

Rates of hospitalisation from anaphylaxis have increased by 50 per cent between 2005 and 2012, a study by Dr Raymond Mullins (John James Medical Centre, Canberra) and Prof Mimi Tang (Murdoch Childrens Research Institute, Melbourne) has found.

In the article published online today in The Journal of Allergy and Clinical Immunology (JACI), Mullins and colleagues examined hospital admission rates to Australian hospitals for treatment of severe life-threatening allergic reactions (anaphylaxis) in the 14 years between 1998 and 2012. The aim was to determine whether childhood food allergy and anaphylaxis has increased further since 2005.

Hospitalisation rates increased in all age groups, and the highest rates were still found in very young children aged less than 5 years. Food allergy was the main cause and the main reason for these higher rates.

"We saw an overall 50% increase in anaphylaxis admissions, and between a 30 and 50% increase in most age groups", said lead researcher Dr Raymond Mullins.

"Importantly, although the highest rates were seen in children under 5years of age, we noted that for older children aged 5-14 years, there was a 110% increase (more than doubling) in rates over this period, much greater than for other age groups. Now 1 out of every 500 hospital admissions in this age group are to treat anaphylaxis. What was most interesting was that while the rate of increase is steady in most groups, we saw an acceleration in the rate of increase in this age group" said Mullins.

"The food allergy generation was born over a decade ago. We are now seeing food allergy and anaphylaxis turn into a chronic condition that for many individuals will not disappear, with a possible eventual flow on effect to rates of fatal food allergic reactions which are most common in these age groups."

"The challenge for our healthcare system will be how we can try to prevent the development of new food allergy development in very young children, how best to care for the increasing numbers of new cases in younger children and how to manage the shifting burden of disease with the greatest increases in older teenagers and young adults"

Food allergy and anaphylaxis have emerged as a major personal and public health burden in developed countries over the last 20 years, contributing to a significant economic cost of care and reduced quality of life for food allergic children and their families.

Reference

Mullins RJ, Dear, KBGMA,  Tang MLK. Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. J Allergy Clin Immunol.  Published Online: July 13, 2015. DOI: http://dx.doi.org/10.1016/j.jaci.2015.05.009

1st author: Dr Raymond Mullins, John James Medical Centre, Canberra, Australia
Co-author: Professor Mimi Tang, Murdoch Childrens Research Institute and The Royal Children's Hospital

Source from original media release Murdoch Childrens Research Institute, Melbourne.

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